{"id":6838,"date":"2024-01-24T15:23:50","date_gmt":"2024-01-24T14:23:50","guid":{"rendered":"https:\/\/www.kfc.upol.cz\/?page_id=6838"},"modified":"2024-01-24T15:24:33","modified_gmt":"2024-01-24T14:24:33","slug":"vb","status":"publish","type":"page","link":"https:\/\/www.kfc.upol.cz\/en\/vb\/","title":{"rendered":"VB"},"content":{"rendered":"[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][vc_column_text]Tel: 58 563 <strong>4769<\/strong>, E-mail:\u00a0<a href=\"mailto:vaclav.bazgier@upol.cz\">vaclav.bazgier@upol.cz<\/a>, Room:\u00a0<strong>3.009<\/strong>\u00a0<a href=\"https:\/\/orcid.org\/0000-0003-3393-3010\"><img decoding=\"async\" title=\"orcid\" src=\"http:\/\/old.fch.upol.cz\/wp-content\/uploads\/2015\/04\/orcid_24x24.png\" alt=\"orcid\" \/><\/a><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-6229 alignright\" src=\"https:\/\/www.kfc.upol.cz\/wp-content\/uploads\/2021\/08\/17.jpg\" alt=\"\" width=\"210\" height=\"210\" srcset=\"https:\/\/www.kfc.upol.cz\/wp-content\/uploads\/2021\/08\/17.jpg 210w, https:\/\/www.kfc.upol.cz\/wp-content\/uploads\/2021\/08\/17-150x150.jpg 150w, https:\/\/www.kfc.upol.cz\/wp-content\/uploads\/2021\/08\/17-100x100.jpg 100w, https:\/\/www.kfc.upol.cz\/wp-content\/uploads\/2021\/08\/17-140x140.jpg 140w\" sizes=\"auto, (max-width: 210px) 100vw, 210px\" \/><\/p>\n<h2>Research interests<\/h2>\n<ul>\n<li>In-silico drug design (molecular docking, chemoinformatics)<\/li>\n<\/ul>\n<h2>Education<\/h2>\n<ul>\n<li>2011 &#8211; V\u0160B \u2013 Technical University of Ostrava<\/li>\n<li>2014 &#8211; University of Ostrava<\/li>\n<li>2018 &#8211; Palack\u00fd University Olomouc<\/li>\n<\/ul>\n<h2>Employment<\/h2>\n<ul>\n<li>2007 &#8211; 2009 &#8211; Department of Biochemistry, Faculty of Science, Palack\u00fd University Olomouc<\/li>\n<li>2009 &#8211; 2011 &#8211; Department of Immunology, Faculty of Medicine and Dentistry, Palack\u00fd University Olomouc<\/li>\n<li>2011 &#8211; 2013 &#8211; Department of Botany, Faculty of Science, Palack\u00fd University Olomouc<\/li>\n<li>2012 &#8211; now &#8211; Laboratory of Growth Regulators, Palack\u00fd University Olomouc<\/li>\n<li>2013 &#8211; 2020 &#8211; Regional Centre of Advanced Technologies and Materials, Palack\u00fd University Olomouc<\/li>\n<li>2020 &#8211; now &#8211; Department of Physical Chemistry, Faculty of Science, Palack\u00fd University Olomouc<\/li>\n<\/ul>\n<h2>Publication<\/h2>\n<h2>2021<\/h2>\n<ol class=\"pubs\">\n<li>Diachkov MV, Ferrer K, Okle\u0161\u0165kov\u00e1 J, Rarov\u00e1 L, Bazgier V, Kvasnica M: Synthesis and Biological Activity of Brassinosteroid Analogues with a Nitrogen-Containing Side Chain.\u00a0<em>Int. J. Mol. Sci., 22(1), 155, 2021<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.3390\/ijms22010155\">DOI<\/a>)<\/li>\n<li>Kiss MA, Pe\u0159ina M, Bazgier V, May NV, Baji \u00c1, Jorda R, Frank \u00c9: Synthesis of dihydrotestosterone derivatives modified in the A-ring with (hetero)arylidene, pyrazolo[1,5-a]pyrimidine and triazolo[1,5-a]pyrimidine moieties and their targeting of the androgen receptor in prostate cancer.\u00a0<em>J. Steroid Biochem. Mol. Biol. , 211, 105904, 2021<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1016\/j.jsbmb.2021.105904\">DOI<\/a>)<\/li>\n<li>Sehnal D, Bittrich S, Deshpande M, Svobodov\u00e1 R, Berka K, Bazgier V, Velankar S, Burley SK, Ko\u010da J, Rose AS: Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures.\u00a0<em>Nucleic Acids Res., 49(W1), W431-W437, 2021<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1093\/nar\/gkab314\">DOI<\/a>)<\/li>\n<li>\u0160pi\u010d\u00e1kov\u00e1 A, Kraus P, Guck\u00fd T, Kry\u0161tof V, Strnad M, Bazgier V, Otyepka M, Kub\u00ed\u010dkov\u00e1 V, Poruba M, R\u00e1cov\u00e1 Z, Zapletalov\u00e1 I, Anzenbacher P: in vitro and in silico Studies of Interaction of Synthetic 2,6,9-Trisubstituted Purine Kinase Inhibitors BPA-302, BP-21 and BP-117 With Liver Drug-Metabolizing Cytochromes P450.\u00a0<em>Physiol. Res., 69(4), S627-S636, 2021<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.33549\/physiolres.934611\">DOI<\/a>)<\/li>\n<\/ol>\n<h2>2020<\/h2>\n<ol class=\"pubs\">\n<li>\u0160lachtov\u00e1 V, \u0160ebela M, Torfs E, oorts L, Cappoen D, Berka K, Bazgier V, Brul\u00edkov\u00e1 L: Novel thiazolidinedione-hydroxamates as inhibitors of Mycobacterium tuberculosis virulence factor Zmp1.\u00a0<em>Eur. J. Med. Chem., 185, 111812, 2020<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1016\/j.ejmech.2019.111812\">DOI<\/a>)<\/li>\n<\/ol>\n<h2>2019<\/h2>\n<ol class=\"pubs\">\n<li>Jorda R, \u0158ezn\u00ed\u010dkov\u00e1 E, Kie\u0142czewska U, Maj J, Morzycki J, Siergiejczyk L, Bazgier V, Berka K, R\u00e1rov\u00e1 L, Wojtkielewicz A: Synthesis of novel galeterone derivatives and evaluation of their in vitro activity against prostate cancer cell lines.\u00a0<em>Eur. J. Med. Chem., 179, 483-492, 2019<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1016\/j.ejmech.2019.06.040\">DOI<\/a>)<\/li>\n<li>Jura\u010dka J, \u0160rejber M, Mel\u00edkov\u00e1 M, Bazgier V, Berka K: MolMeDB: Molecules on Membranes Database.\u00a0<em>Database, 2019, baz078, 2019<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1093\/database\/baz078\">DOI<\/a>)<\/li>\n<li>\u0160pi\u010d\u00e1kov\u00e1 A, Bazgier V, Sk\u00e1lov\u00e1 L, Otyepka M, Anzenbacher P: Beta-caryophyllene oxide and trans-nerolidol affect enzyme activity of CYP3A4-in vitro and in silico studies.\u00a0<em>Physiol. Res., 68, S51-S58, 2019<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.33549\/physiolres.934323\">DOI<\/a>)<\/li>\n<\/ol>\n<h2>2018<\/h2>\n<ol class=\"pubs\">\n<li>Guck\u00fd T, \u0158ezn\u00ed\u010dkov\u00e1 E, Muchov\u00e1 RT, Jorda R, Klejov\u00e1 Z, Mal\u00edkov\u00e1 V, Berka K, Bazgier V, Ajani H, Lep\u0161\u00edk M, Divok\u00fd V, Kry\u0161tof V: Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl-N6-(4-morpholin-4-ylmethyl-phenyl)-9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 mutations.\u00a0<em>J. Med. Chem., 61(9), 3855\u20133869, 2018<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1021\/acs.jmedchem.7b01529\">DOI<\/a>)<\/li>\n<li>Pravda L, Sehnal D, Tou\u0161ek D, Navr\u00e1tilov\u00e1 V, Bazgier V, Berka K, Svobodov\u00e1 Va\u0159ekov\u00e1 R, Ko\u010da J, Otyepka M: MOLEonline: a web-based tool for analyzing channels, tunnels and pores (2018 update).\u00a0<em>Nucleic Acids Res, 46(W1), W368\u2013W373, 2018<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1093\/nar\/gky309\">DOI<\/a>)<\/li>\n<li>\u0160rejber M, Navr\u00e1tilov\u00e1 V, Palonc\u00fdov\u00e1 M, Bazgier V, Berka K, Anzenbacher P, Otyepka M: Membrane-attached mammalian cytochromes P450: An overview of the membrane&#8217;s effects on structure, drug binding, and interactions with redox partners.\u00a0<em>J Inorg Biochem, 183, 117-136, 2018<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1016\/j.jinorgbio.2018.03.002\">DOI<\/a>)<\/li>\n<\/ol>\n<h2>2017<\/h2>\n<ol class=\"pubs\">\n<li>Carazo Fern\u00e1ndez A, Hyrsova L, Du\u0161ek J, Chodounsk\u00e1 H, Horv\u00e1tov\u00e1 A, Berka K, Bazgier V, Gan-Schreier H, Chamulitrat W, Kudov\u00e1 E, P\u00e1vek P: Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor.\u00a0<em>Toxicol. Lett., 265, 86\u201396, 2017<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1016\/j.toxlet.2016.11.013\">DOI<\/a>)<\/li>\n<li>Huli\u010diak M, Bazgier V, Berka K, Kubala M: RH421 binds into the ATP-binding site on the Na+\/K+-ATPase.\u00a0<em>Biochim. Biophys. Acta, Biomembranes, 1859(10), 2113\u20132122, 2017<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1016\/j.bbamem.2017.07.016\">DOI<\/a>)<\/li>\n<li>Ko\u0159\u00ednkov\u00e1 P, Bazgier V, Okle\u0161\u0165kov\u00e1 J, R\u00e1rov\u00e1 L, Strnad M, Kvasnica M: Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study.\u00a0<em>Steroids, 127, 46-55, 2017<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1016\/j.steroids.2017.08.010\">DOI<\/a>)<\/li>\n<\/ol>\n<h2>2016<\/h2>\n<ol class=\"pubs\">\n<li>Baltus CB, Jorda R, Marot C, Berka K, Bazgier V, Kry\u0161tof V, Pri\u00e9 G, Viaud-Massuard M: Synthesis, Biological Evaluation and Molecular Modeling of a Novel Series of 7-Azaindole Based Tri-Heterocyclic Compounds as Potent CDK2\/Cyclin E Inhibitors.\u00a0<em>Eur. J. Med. Chem., 108(27), 701\u2013719, 2016<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1016\/j.ejmech.2015.12.023\">DOI<\/a>)<\/li>\n<li>Bazgier V, Berka K, Otyepka M, Ban\u00e1\u0161 P: Exponential repulsion improves structural predictability of molecular docking.\u00a0<em>J. Comput. Chem., 37(28), 2485\u20132494, 2016<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1002\/jcc.24473\">DOI<\/a>)<\/li>\n<li>Kvasnica M, Okle\u0161\u0165kov\u00e1 J, Bazgier V, R\u00e1rov\u00e1 L, Ko\u0159\u00ednkov\u00e1 P, Mikul\u00edk J, Bud\u011b\u0161\u00ednsk\u00fd M, B\u00e9res T, Berka K, Lu Q, Russinova E, Strnad M: Design, synthesis and biological activities of new brassinosteroid analogues with phenyl group in the side chain.\u00a0<em>Org. Biomol. Chem. , 14(37), 8691-8701, 2016<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1039\/C6OB01479H\">DOI<\/a>)<\/li>\n<li>Lamie PF, Ali WAM, Bazgier V, R\u00e1rov\u00e1 L: Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study.\u00a0<em>Eur. J. Med. Chem., 123, 803\u2013813, 2016<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1016\/j.ejmech.2016.08.013\">DOI<\/a>)<\/li>\n<li>Nisler J, Kope\u010dn\u00fd D, Kon\u010dit\u00edkov\u00e1 R, Zatloukal M, Bazgier V, Berka K, Zalab\u00e1k D, Briozzo P, Strnad M, Sp\u00edchal L: Novel thidiazuron-derived inhibitors of cytokinin oxidase\/dehydrogenase.\u00a0<em>Plant. Mol. Biol., 92(1), 235\u2013248, 2016<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1007\/s11103-016-0509-0\">DOI<\/a>)<\/li>\n<\/ol>\n<h2>2015<\/h2>\n<ol class=\"pubs\">\n<li>\u0158ezn\u00ed\u010dkov\u00e1 E, Popa A, Guck\u00fd T, Zatloukal M, Havl\u00ed\u010dek L, Bazgier V, Berka K, Jorda R, Popa I, Nasereddin A, Jaffe CL, Kry\u0161tof V, Strnad M: 2,6,9-Trisubstituted purines as CRK3 kinase inhibitors with antileishmanial activity in vitro.\u00a0<em>Bioorg. Med. Chem. Lett., 25(11), 2298-2301, 2015<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1016\/j.bmcl.2015.04.030\">DOI<\/a>)<\/li>\n<li>\u0158ezn\u00ed\u010dkov\u00e1 E, Weitensteiner S, Havl\u00ed\u010dek L, Jorda R, Guck\u00fd T, Berka K, Bazgier V, Zahler S, Kry\u0161tof V, Strnad M: Characterization of a Pyrazolo[4,3- d ]pyrimidine Inhibitor of Cyclin-Dependent Kinases 2 and 5 and Aurora A With Pro-Apoptotic and Anti-Angiogenic Activity In Vitro.\u00a0<em>Chem. Biol. Drug. Des., 86(6), 1528\u20131540, 2015<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1111\/cbdd.12618\">DOI<\/a>)<\/li>\n<\/ol>\n<h2>2014<\/h2>\n<ol class=\"pubs\">\n<li>Kvasnica M, Okle\u0161\u0165kov\u00e1 J, Bazgier V, R\u00e1rov\u00e1 L, Berka K, Strnad M: Biological activities of new monohydroxylated brassinosteroid analogues with a carboxylic group in the side chain.\u00a0<em>Steroids, 85, 58-64, 2014<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1016\/j.steroids.2014.04.007\">DOI<\/a>)<\/li>\n<li>Mojzych M, \u0160ubertov\u00e1 V, Bielawska A, Bielawski K, Bazgier V, Berka K, Guck\u00fd T, Fornal E, Kry\u0161tof V: Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines.\u00a0<em>Eur. J. Med. Chem., 78, 217-224, 2014<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1016\/j.ejmech.2014.03.054\">DOI<\/a>)<\/li>\n<\/ol>\n<h2>2013<\/h2>\n<ol class=\"pubs\">\n<li>Guck\u00fd T, Jorda R, Zatloukal M, Bazgier V, Berka K, \u0158ezn\u00ed\u010dkov\u00e1 E, B\u00e9res T, Strnad M, Kry\u0161tof V: A Novel Series of Highly Potent 2,6,9-Trisubstituted Purine Cyclin-Dependent Kinase Inhibitors.\u00a0<em>J. Med. Chem., 56(15), 6234-6247, 2013<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1021\/jm4006884\">DOI<\/a>)<\/li>\n<li>Havl\u00edkov\u00e1 M, Huli\u010diak M, Bazgier V, Berka K, Kubala M: Fluorone dyes have binding sites on both cytoplasmic and extracellular domains of Na,K-ATPase.\u00a0<em>Biochim. Biophys. Acta, Biomembr., 1828(2), 568-576, 2013<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1016\/j.bbamem.2012.10.029\">DOI<\/a>)<\/li>\n<li>Pozharitskaya O, Shikov A, Makarova M, Ivanova S, Kosman V, Makarov V, Bazgier V, Berka K, Otyepka M, Ulrichov\u00e1 J: Antiallergic Effects of Pigments Isolated from Green Sea Urchin (Strongylocentrotus droebachiensis) Shells.\u00a0<em>Planta Med., 79(18), 1698-1704, 2013<\/em>. (<a href=\"https:\/\/dx.doi.org\/10.1055\/s-0033-1351098\">DOI<\/a>)<\/li>\n<\/ol>\n[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221;&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6838","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/www.kfc.upol.cz\/en\/wp-json\/wp\/v2\/pages\/6838","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kfc.upol.cz\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.kfc.upol.cz\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.kfc.upol.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kfc.upol.cz\/en\/wp-json\/wp\/v2\/comments?post=6838"}],"version-history":[{"count":1,"href":"https:\/\/www.kfc.upol.cz\/en\/wp-json\/wp\/v2\/pages\/6838\/revisions"}],"predecessor-version":[{"id":6839,"href":"https:\/\/www.kfc.upol.cz\/en\/wp-json\/wp\/v2\/pages\/6838\/revisions\/6839"}],"wp:attachment":[{"href":"https:\/\/www.kfc.upol.cz\/en\/wp-json\/wp\/v2\/media?parent=6838"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}