{"id":7193,"date":"2025-06-03T11:37:16","date_gmt":"2025-06-03T09:37:16","guid":{"rendered":"https:\/\/www.kfc.upol.cz\/?page_id=7193"},"modified":"2025-06-19T15:04:39","modified_gmt":"2025-06-19T13:04:39","slug":"vyzkumne-skupiny","status":"publish","type":"page","link":"https:\/\/www.kfc.upol.cz\/en\/vyzkum\/vyzkumne-skupiny\/","title":{"rendered":"Research groups"},"content":{"rendered":"[vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][divider line_type=”No Line” custom_height=”100″][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]The Department of Physical Chemistry is divided into five research groups, each focusing on research in various areas of application of physicochemical methods.<\/p>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” id=”aplikace” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_custom_heading text=”Applied Physical Chemistry in Nanomaterials Chemistry”][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]\n

The group\u2019s expertise connects the internal structure of material systems<\/strong> across a wide range of input materials\u2014considering phase composition<\/strong> (e.g. gel systems, colloidal dispersions, micellar systems, nanocomposites, interfacial surfaces), chemical composition<\/strong> (e.g. biopolymer systems, synthetic polymers, mineral inorganic systems, active pharmaceutical ingredients, composite materials), and final morphological forms<\/strong> (e.g. porous foam systems, solid bodies, laminated layers). These are studied in relation to their resulting physicochemical, biological, and material performance properties<\/strong>, such as strength, flexibility, hardness, fluidity, brittleness, toughness, adhesiveness, biocompatibility, wettability, surface topology, surface energy distribution, and others.<\/p>\n

The group\u2019s activities have a strong international dimension, involving collaboration with research teams abroad (e.g. University of Birmingham, University of New Orleans, Polish Academy of Sciences in Krakow, Slovak University of Technology in Bratislava, Ghent University, among others). A significant part of the work is also connected to applied industrial research, with current implementation of EP 3 034 693 B1 (2018) in manufacturing processes. In the academic domain, the group is actively involved in a number of applied and basic research projects.<\/p>\n

 <\/p>\n

Group members:<\/strong><\/p>\n

Prof. Ing. Lubom\u00edr Lap\u010d\u00edk, Ph.D.<\/a> – head of group<\/p>\n

Doc. Mgr. Barbora Lap\u010d\u00edkov\u00e1, Ph.D.<\/a><\/p>\n

Mgr. Jakub Vl\u010dek, Ph.D.<\/p>\n

RNDr. Eva Otyepkov\u00e1, Ph.D.<\/a><\/p>\n

MSc. Yousef Murtaja (Ph.D.student)<\/p>\n

Mgr. David \u0158epka (Ph.D. student)[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”default” animate=”yes” custom_height=”150″][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” id=”bio” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_custom_heading text=”Nanomateri\u00e1ly pro biologick\u00e9 a l\u00e9ka\u0159sk\u00e9 aplikace”][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]Odborn\u00e9 zam\u011b\u0159en\u00ed skupiny c\u00edl\u00ed na synt\u00e9zu, charakterizaci a studium fyzik\u00e1ln\u011b chemick\u00fdch a biologick\u00fdch vlastnost\u00ed nanostrukturn\u00edch materi\u00e1l\u016f<\/strong>. V\u00fdzkum je zam\u011b\u0159en zejm\u00e9na na \u0159\u00edzenou synt\u00e9zu biologicky aktivn\u00edch nanomateri\u00e1l\u016f s\u00a0c\u00edlenou morfologi\u00ed vyu\u017eiteln\u00fdch p\u0159edev\u0161\u00edm v\u00a0l\u00e9ka\u0159sk\u00e9 diagnostice a terapii<\/strong>. Mezi takov\u00e9 nanomateri\u00e1ly pat\u0159\u00ed mimo jin\u00e9 nano\u010d\u00e1stice u\u0161lechtil\u00fdch kov\u016f jako je st\u0159\u00edbro a zlato, kter\u00e9 lze d\u00edky jejich unik\u00e1tn\u00edm chemick\u00fdm, fyzik\u00e1ln\u00edm, optick\u00fdm a biologick\u00fdm vlastnostem vyu\u017e\u00edt nap\u0159. k\u00a0diagnostice \u010di terapii cel\u00e9 \u0159ady chronick\u00fdch onemocn\u011bn\u00ed jako jsou n\u00e1dorov\u00e1 \u010di infek\u010dn\u00ed onemocn\u011bn\u00ed. Mezi konkr\u00e9tn\u00ed sm\u011bry v\u00fdzkumu pat\u0159\u00ed synt\u00e9za plasmonick\u00fdch nano\u010d\u00e1stic st\u0159\u00edbra a zlata a jejich vyu\u017eit\u00ed jako nano-biosenzory k\u00a0detekci specifick\u00fdch l\u00e1tek (marker\u016f) z\u00e1va\u017en\u00fdch onemocn\u011bn\u00ed<\/strong> a sou\u010dasn\u011b jako nano-terapeutika pro eliminaci n\u00e1dorov\u00fdch bun\u011bk \u010di patogenn\u00edch bakteri\u00ed<\/strong> prost\u0159ednictv\u00edm sv\u011btlem asistovan\u00e9 fotodynamick\u00e9 \u010di fototerm\u00e1ln\u00ed terapie.<\/p>\n

V\u00fdzkumn\u00e9 zam\u011b\u0159en\u00ed skupiny je \u00fazce spjato a nav\u00e1z\u00e1no na spolupr\u00e1ci s\u00a0odborn\u00fdmi pracovi\u0161ti L\u00e9ka\u0159sk\u00e9 fakulty Univerzity Palack\u00e9ho (\u00dastav mikrobiologie, \u00dastav l\u00e9ka\u0159sk\u00e9 biofyziky, \u00dastav farmakologie a dal\u0161\u00ed), Farmaceutick\u00e9 fakulty UK v\u00a0Hradci Kr\u00e1lov\u00e9 a rovn\u011b\u017e se zahrani\u010dn\u00edmi pracovi\u0161ti jako je Paris Lodron Universit\u00e4t Salzburg (Rakousko) a University of Pisa (It\u00e1lie). \u010clenov\u00e9 v\u00fdzkumn\u00e9 skupiny jsou v\u00a0r\u00e1mci v\u011bdeck\u00e9ho v\u00fdzkumu aktivn\u011b zapojeni do \u0159e\u0161en\u00ed grantov\u00fdch projekt\u016f (Grantov\u00e1 Agentuta \u010cR, Ministerstvo zdravotnictv\u00ed) zam\u011b\u0159en\u00fdch na v\u00fdzkum p\u0159\u00edpravy a aplikace nano\u010d\u00e1stic st\u0159\u00edbra v\u00a0in vitro<\/em> a in vivo<\/em> terapii infek\u010dn\u00edch onemocn\u011bn\u00ed zp\u016fsoben\u00fdch rezistentn\u00edmi patogeny.<\/p>\n

 <\/p>\n

\u010clenov\u00e9 skupiny:<\/strong><\/p>\n

doc. RNDr. Ale\u0161 Pan\u00e1\u010dek, Ph.D.<\/a><\/p>\n

Mgr. Lucie Hochvaldov\u00e1 (Ph.D. student)<\/p>\n

Mgr. Ant\u00f3nia Kurillov\u00e1 (Ph.D. student)[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”default” animate=”yes” custom_height=”150″][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” id=”katalyza” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_custom_heading text=”Nanomateri\u00e1ly pro katalytick\u00e9 a spektroskopick\u00e9 aplikace”][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]Hlavn\u00edm c\u00edlem v\u011bdecko-v\u00fdzkumn\u00fdch aktivit skupiny je propojen\u00ed aplika\u010dn\u00edho potenci\u00e1lu s\u00a0p\u0159\u00edpravami nanomateri\u00e1l\u016f<\/strong> a jejich n\u00e1sledn\u00e9 vyu\u017eit\u00ed v\u00a0katalytick\u00e9, fotokatalytick\u00e9 a environment\u00e1ln\u00ed oblasti<\/strong>.<\/p>\n

Synt\u00e9zy nanomateri\u00e1l\u016f, p\u0159\u00edpadn\u011b kompozitn\u00edch materi\u00e1l\u016f, jsou zam\u011b\u0159eny p\u0159edev\u0161\u00edm na uhl\u00edkov\u00e9 materi\u00e1ly (grafen oxid, nitrid uhl\u00edku), nano\u010d\u00e1stice oxid\u016f \u017eeleza a dal\u0161\u00edch slou\u010denin, kter\u00e9 se vyu\u017e\u00edvaj\u00ed jako samostatn\u00fd prekurzor, nebo jsou modifikov\u00e1ny nano\u010d\u00e1sticemi (Ag, Au, Cu, Ni, Se), dopov\u00e1ny r\u016fzn\u00fdmi prvky (N,P,B) \u010di obohacov\u00e1ny funk\u010dn\u00edmi skupinami. Snahou je z\u00edskat funk\u010dn\u00ed materi\u00e1ly pro specifickou aplikaci s vysok\u00fdm aplika\u010dn\u00edm potenci\u00e1lem.<\/p>\n

U konkr\u00e9tn\u00edch materi\u00e1l\u016f se v\u00a0r\u00e1mci v\u00fdzkumn\u00e9 skupiny soust\u0159ed\u00edme na jejich katalytickou aktivitu<\/strong> v\u00a0plynn\u00e9 a kapaln\u00e9 f\u00e1zi, nap\u0159. hydrogenace CO2<\/sub> a jeho p\u0159em\u011bna na vy\u0161\u0161\u00ed uhlovod\u00edky, a na jejich fotokatalytick\u00fd potenci\u00e1l, tedy schopnost fotodegradace polutant\u016f v\u00a0\u017eivotn\u00edm prost\u0159ed\u00ed (nap\u0159. odstra\u0148ov\u00e1n\u00ed organick\u00fdch l\u00e1tek a mikroplast\u016f). Oblast heterogenn\u00ed fotokatal\u00fdzy je tak\u00e9 \u00fazce spjata se\u00a0\u201ezelenou\u201c produkc\u00ed vod\u00edku a fixac\u00ed dus\u00edku z\u00a0\u017eivotn\u00edho prost\u0159ed\u00ed.<\/p>\n

Dal\u0161\u00edm v\u00fdzkumn\u00fdm zam\u011b\u0159en\u00edm je p\u0159\u00edprava plasmonick\u00fdch nano\u010d\u00e1stic kov\u016f, jejich kompozit\u016f a nanostrukturovan\u00fdch povrch\u016f pro spektroskopick\u00e9 aplikace<\/strong>, zejm\u00e9na pro p\u0159\u00edpravu senzor\u016f<\/strong> ur\u010den\u00fdch k\u00a0detekci n\u00edzk\u00fdch koncentrac\u00ed biologicky v\u00fdznamn\u00fdch l\u00e1tek (nap\u0159. biomarker\u016f neurologick\u00fdch \u010di jin\u00fdch onemocn\u011bn\u00ed) pomoc\u00ed povrchem zes\u00edlen\u00e9 Ramanovy spektroskopie (SERS).<\/p>\n

V\u00fdzkumn\u00e9 aktivity jsou podpo\u0159eny \u0159adou spoluprac\u00ed, zejm\u00e9na s\u00a0Akademi\u00ed v\u011bd \u010cR v\u00a0Praze, s\u00a0P\u0159\u00edrodov\u011bdeckou fakultou Ostravsk\u00e9 univerzity, s Univerzitou v\u00a0Pise a s\u00a0Univerzitou of Silesia, konkr\u00e9tn\u011b s MacroSynth group v\u00a0Katowic\u00edch.<\/p>\n

\u010clenov\u00e9 skupiny:<\/strong><\/p>\n

doc. RNDr. Robert Prucek, Ph.D.<\/a><\/p>\n

prof. RNDr. Libor Kv\u00edtek, CSc.<\/a><\/p>\n

Ing. Arkadii Bikbashev,\u00a0 M.Sc. (Ph.D. student)<\/p>\n

Mgr. Aneta Bu\u017ekov\u00e1 (Ph.D. studentka)<\/p>\n

Mgr. Martina Kaj\u00e1bov\u00e1 (Ph.D. studentka)<\/p>\n

Mgr. Ing. Radka Pocklanov\u00e1 (Ph.D. studentka)<\/p>\n

Mgr. Karol\u00edna Simkovi\u010dov\u00e1 (Ph.D. studentka)<\/p>\n

Mgr. Tom\u00e1\u0161 Stry\u0161ovsk\u00fd (Ph.D. student)<\/p>\n

Mgr. Barbora \u0160tefkov\u00e1 (Ph.D. studentka)<\/p>\n

Ing. Ad\u00e9la \u017di\u017elavsk\u00e1, Ph.D. (Ph.D. studentka)[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” id=”Chemical_data” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”default” animate=”yes” custom_height=”150″][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_custom_heading text=”Chemical Data”][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]The research group focuses on chemical data in the context of biological systems.<\/p>\n

The main research areas include structural bioinformatics of proteins<\/strong> and the application of computational molecular modeling<\/strong> methods for the design of the structure\u2013activity relationships of new low-molecular-weight compounds targeting specific biological effects.<\/p>\n

Another focus of the group is the development and operation of chemical databases and tools. The MolMeDB<\/a> database collects physicochemical data on interactions of low-molecular-weight compounds with membranes (https:\/\/molmedb.upol.cz\/<\/a>). The ChannelsDB<\/a> database and the MOLEonline<\/a> tool are dedicated to the study of tunnels in proteins (https:\/\/moleonline.cz\/<\/a>).<\/p>\n

The group collaborates with other research teams within Palack\u00fd University on compound design (Assoc. Prof. Brul\u00edkov\u00e1, KOCH; Assoc. Prof. Kry\u0161tof, Assoc. Prof. Jorda, KEB; Prof. Strnad, Assoc. Prof. Nov\u00e1k, LRR), participation in the ELIXIR CZ infrastructure for biological data<\/a> (Assoc. Prof. Hajd\u00fach, Dr. Polishchuk, Dr. Vrbkov\u00e1, UMTM), chemical data map visualization (Assoc. Prof. Burian, KGI), and research infrastructures within the Aurora university alliance<\/a> (Assoc. Prof. N\u00e9tek, KGI).<\/p>\n

Additionally, the group cooperates with teams outside Palack\u00fd University, including ELIXIR CZ projects such as protein visualization tools \u2014 LiteMol<\/a>, Mol*<\/a>, 2Dprots<\/a>, Overprot<\/a>, ACC, Alphacharges<\/a> (Assoc. Prof. Svobodov\u00e1, Dr. Sehnal, CEITEC MUNI); chemical data interoperability \u2014 IDSM (Prof. Vondr\u00e1\u0161ek, Dr. Galgonek, UOCHB); data management \u2014 DataStewardshipWizard (Assoc. Prof. Pergl, CTU); and Alphafold research (Dr. Novotn\u00fd, Faculty of Science, Charles University). Furthermore, we collaborate on the development of novel liposomal drug carriers (Prof. \u0160t\u011bp\u00e1nek, UCT Prague), leveraging knowledge of compound\u2013membrane interactions.<\/p>\n

Group members:<\/strong><\/p>\n

doc. RNDr. Karel Berka, Ph.D.<\/a> – head of group<\/p>\n

Mgr. Ing. V\u00e1clav Bazgier, Ph.D.<\/a><\/p>\n

Mgr. Jakub Jura\u010dka<\/p>\n

Mgr. Martin \u0160rejber (Ph.D. student)<\/p>\n

Mgr. Michaela Jarom\u011b\u0159sk\u00e1 (Ph.D. studentka, rodi\u010dovsk\u00e1)<\/p>\n

Mgr. Kate\u0159ina Storchmannov\u00e1 (Ph.D. studentka)<\/p>\n

Mgr. Dominik Martin\u00e1t (Ph.D. student)<\/p>\n

Mgr. Anna \u0160pa\u010dkov\u00e1 (Ph.D. studentka)<\/p>\n

Bc. Nina Kad\u00e1\u0161ov\u00e1 (Mgr. studentka)<\/p>\n

Bc. Jan Mach\u00e1\u0148 (Mgr. student)<\/p>\n

Jan Urb\u00e1nek (Bc. student)[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”default” animate=”yes” custom_height=”150″][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” id=”data” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_custom_heading text=”Po\u010d\u00edta\u010dov\u00e9 modelov\u00e1n\u00ed biostruktur”][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]Skupina se zab\u00fdv\u00e1 studiem struktury a dynamiky biomolekul, s vyu\u017eit\u00edm prost\u0159edk\u016f po\u010d\u00edta\u010dov\u00e9ho modelov\u00e1n\u00ed, zejm\u00e9na metod molekulov\u00e9 dynamiky a \u010d\u00e1ste\u010dn\u011b i kvantov\u00e9 chemie.<\/p>\n

Hlavn\u00ed v\u00fdzkumn\u00fd z\u00e1jem sm\u011b\u0159uje k\u00a0m\u00e9n\u011b obvykl\u00fdm (tzv. nekanonick\u00fdm), ale o to zaj\u00edmav\u011bj\u0161\u00edm form\u00e1m nukleov\u00fdch kyselin, jako jsou guaninov\u00e9 kvadruplexy (G-kvadruplexy), Z-DNA nebo i-motiv DNA. Dal\u0161\u00edm d\u016fle\u017eit\u00fdm sm\u011brem je studium interakc\u00ed nukleov\u00fdch kyselin s\u00a0proteiny, jak specifick\u00fdch (nap\u0159. s\u00a0regulatorn\u00edmi proteiny), tak nespecifick\u00fdch.<\/p>\n

Sou\u010d\u00e1st\u00ed v\u00fdzkumu skupiny je tak\u00e9 v\u00fdvoj empirick\u00fdch potenci\u00e1l\u016f pro molekulovou dynamiku nukleov\u00fdch kyselin (http:\/\/ffol.upol.cz<\/a>). Na\u0161e potenci\u00e1ly jsou pou\u017e\u00edv\u00e1ny po cel\u00e9m sv\u011bt\u011b a nesou zkratku \u201eOL\u201c podle OLOMOUCE, m\u00edsta, kde byly vyvinuty.<\/p>\n

Po\u010d\u00edta\u010dov\u00e9 modelov\u00e1n\u00ed \u010dasto poskytuje jasn\u011bj\u0161\u00ed a detailn\u011bj\u0161\u00ed pohled na procesy prob\u00edhaj\u00edc\u00ed v\u00a0biomolekul\u00e1ch ne\u017e experiment\u00e1ln\u00ed metody, i kdy\u017e jen na relativn\u011b kr\u00e1tk\u00fdch \u010dasov\u00fdch \u0161k\u00e1l\u00e1ch omezen\u00fdch v\u00fdpo\u010detn\u00ed silou sou\u010dasn\u00fdch superpo\u010d\u00edta\u010d\u016f. D\u00edky nezadr\u017eiteln\u00e9mu n\u00e1r\u016fstu v\u00fdkonu po\u010d\u00edta\u010d\u016f se ale metody v\u00fdpo\u010detn\u00ed chemie st\u00e1vaj\u00ed st\u00e1le mocn\u011bj\u0161\u00edmi a prosazuj\u00ed se i v\u00a0praxi nap\u0159. p\u0159i racion\u00e1ln\u00edm n\u00e1vrhu l\u00e9\u010div.<\/p>\n

Spolupracujeme s\u00a0n\u011bkolika zahrani\u010dn\u00edmi pracovi\u0161ti, nap\u0159. University of Barcelona ve \u0160pan\u011blsku, CNRS v\u00a0Pa\u0159\u00ed\u017ei, University of Utah v\u00a0USA a s\u00a0dom\u00e1c\u00edmi pracovi\u0161ti na UOCHB v\u00a0Praze, IBP v\u00a0Brn\u011b a OU v\u00a0Ostrav\u011b.<\/p>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]\u010clenov\u00e9 skupiny:<\/strong><\/p>\n

doc. RNDr. Petr Jure\u010dka, Ph.D.<\/a><\/p>\n

Mgr. Marie Zgarbov\u00e1, Ph.D.<\/a><\/p>\n

Mgr. Ji\u0159\u00ed Fukal<\/p>\n

Bc. Anna Jelinkov\u00e1 (Mgr. studentka)<\/p>\n

Bc. Elizabeth Kol\u00e1\u0159ov\u00e1 (Mgr. studentka)<\/p>\n

Bc. Jan Salomon (Mgr. student)<\/p>\n

Filip Samoh\u00fdl (Bc. student)<\/p>\n

Rebeka Tr\u00e9fov\u00e1 (Bc. studentka)[\/vc_column_text][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”3\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][image_with_animation image_url=”6402″ image_size=”medium_large” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”none” alignment=”center” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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